Depression vs. Annoyance

So if anyone out there has any kind of anxiety or depression you know that people like to blame your "blow-ups" on your "illness".  But what about the possibility that there are outside influences that aggravate your condition. Several times in my life I have had someone ask me if I had taken my meds...usually during a heated conversation about things that upset me.  I am not ignorant to the fact that I am subject to mood swings.  Sometimes my friends and family are unfortunate victims of my random outbursts.  But as I learn to manage myself in a healthy manner do the people closest to me not have a responsibility to be sensitive to my mood?  Or is it a matter of it not being their problem. I know I would at least try not to push peoples buttons (I don't pretend not to have made several mistakes myself tho)  And if someone pushes my buttons, do I not have a right to react...even if it's a little more exaggerated than normal.  Where do my rights go when I'm sick and how can I really know if I am overreacting until it's too late? And who do you talk to if your friends run for cover too....